BMS 777607 CAS: 1025720-94-8
MF: C25H19ClF2N4O4
MW: 512.89
A small-molecule inhibitor of Met, Axl, Ron and Tyro3.

BMS 777607 (CAS 1025720-94-8)

BMS 777607 | CAS 1025720-94-8 is rated 5.0 out of 5 by 1.
  • y_2020, m_8, d_2, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_364438, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 183ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Application: BMS 777607 is a small-molecule inhibitor of Met, Axl, Ron and Tyro3
CAS Number: 1025720-94-8
Molecular Weight: 512.89
Molecular Formula: C25H19ClF2N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

BMS 777607 is a small-molecule Met-related kinases inhibitor of Met (IC50 = 3.9 nM), Axl (IC50 = 1.1 nM), Ron (IC50 = 1.8 nM), and Tyro3 (IC50 = 4.3 nM).


References

PMID: 19260711 PMID: 20515943 PMID: 22286523 PMID: 18690676

Physical State :
Solid
Solubility :
Soluble in DMSO (47 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), ethanol (< 1 mg/ml at 25 °C), and 1% DMSO/30% polyethylene glycol/1% Tween 80 (30 mg/ml at 25 °C).
Storage :
Store at -20° C
Boiling Point :
~667.9° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
Axl: IC50 = 1.1 nM; Ron: IC50 = 1.8 nM; c-Met: IC50 = 3.9 nM; Tyro3: IC50 = 4.3 nM
pK Values :
pKa: 10.54 (Predicted), pKb: 3.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24794418
MDL Number :
MFCD16495773
SMILES :
CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

BMS 777607 (CAS 1025720-94-8)  Product Citations

See how others have used BMS 777607 (CAS 1025720-94-8). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31531847  Eur. J. Immunol. 48-55.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 132ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Nurhayati Nurhayati, RW. et al. (PubMed 25304900) reported that BMS 777607 promotes megakaryocytic differentiation and induces polyploidization in CHRF-288-11 cells. -SCBT Publication Review
Date published: 2015-04-21
  • y_2020, m_8, d_2, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_364438, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 33ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.