BMS 777607A small-molecule inhibitor of Met, Axl, Ron and Tyro3

BMS 777607 (CAS 1025720-94-8)

BMS 777607 | CAS 1025720-94-8 is rated 5.0 out of 5 by 1.
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Synonym: N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Application: A small-molecule inhibitor of Met, Axl, Ron and Tyro3
CAS Number: 1025720-94-8
Molecular Weight: 512.89
Molecular Formula: C25H19ClF2N4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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BMS 777607 is a small-molecule Met-related kinases inhibitor of Met (IC50 = 3.9 nM), Axl (IC50 = 1.1 nM), Ron (IC50 = 1.8 nM), and Tyro3 (IC50 = 4.3 nM).


References

PMID: 19260711 PMID: 20515943 PMID: 22286523 PMID: 18690676

Physical State :
Solid
Solubility :
Soluble in DMSO (47 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), ethanol (< 1 mg/ml at 25 °C), and 1% DMSO/30% polyethylene glycol/1% Tween 80 (30 mg/ml at 25 °C).
Storage :
Store at -20° C
Boiling Point :
~667.9° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
Axl: IC50 = 1.1 nM; Ron: IC50 = 1.8 nM; c-Met: IC50 = 3.9 nM; Tyro3: IC50 = 4.3 nM
pK Values :
pKa: 10.54 (Predicted), pKb: 3.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24794418
MDL Number :
MFCD16495773
SMILES :
CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Nurhayati Nurhayati, RW. et al. (PubMed 25304900) reported that BMS 777607 promotes megakaryocytic differentiation and induces polyploidization in CHRF-288-11 cells. -SCBT Publication Review
Date published: 2015-04-21
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