BMS 470539 dihydrochloride CAS: 457893-92-4
MF: C32H41N5O4•2HCl
MW: 632.62
A selective and potent agonist of melanocortin receptor (MC1-R).

BMS 470539 dihydrochloride (CAS 457893-92-4)

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Alternate Names: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride
Application: BMS 470539 dihydrochloride is a selective and potent agonist of melanocortin receptor (MC1-R)
CAS Number: 457893-92-4
Molecular Weight: 632.62
Molecular Formula: C32H41N5O42HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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BMS 470539 dihydrochloride is a selective MC1-R (melanocortin receptor) agonist (IC50 = 120 nM). This compound also inhibits leukocyte trafficking and displays anti-inflammatory properties following ischemia-reperfusion in the vasculature.


References

1. Chen, X., Et al. 2017. Ann Neurol. 81(3): 395-406. PMID: 28019657

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
MC1-R: EC5050 = 28 nM (human); MC1-R: IC50 = 120 nM; MC4-R: EC5050 = 2.6 µM (human); MC5-R: EC5050 = 4.4 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD19690933
SMILES :
CCCC(=O)C1(CCN(CC1)C(=O)[[email protected]@H](CC2=CC=C(C=C2)OC)NC(=O)[[email protected]](CC3=CN=CN3C)N)C4=CC=CC=C4.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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BMS 470539 dihydrochloride (CAS 457893-92-4)  Product Citations

See how others have used BMS 470539 dihydrochloride (CAS 457893-92-4). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 33468172  Yu, S.|Doycheva, DM.|Gamdzyk, M.|Yang, Y.|Lenahan, C.|Li, G.|Li, D.|Lian, L.|Tang, J.|Lu, J.|Zhang, JH.| et al. 2021. J Neuroinflammation. 18: 26.

PMID: # 31486022  Neurotherapeutics.

PMID: # 33391490  Theranostics. 522-539.

Citations 1 to 3 of 3 total

Does this chemical compound could pass blood-brain barrier ?

Asked by: weilin xu
We do not recommend nor support the use of our chemicals for in vitro research applications. However, to answer your question, according to the below journal article BMS 470539 dihydrochloride has modest blood–brain barrier penetrance. Chen, X., Et al. 2017. Ann Neurol. 81(3): 395-406. PMID: 28019657
Answered by: Technical Support
Date published: 2019-09-11
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