BML-286A Wnt signaling disrupter and cancer cell growth inhibitor

BML-286 (CAS 294891-81-9)

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Synonym: 2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]benzoic acid
Application: A Wnt signaling disrupter and cancer cell growth inhibitor
CAS Number: 294891-81-9
Molecular Weight: 374.38
Molecular Formula: C22H18N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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BML-286 is a cell-permeable compound whose binding of the PDZ domain of dishevelled (Kd = 10.6 µM) disrupts Wnt signaling. Further, BML-286 blocked Wnt3a-induced transcription activity and was able to suppress the Wnt pathway-dependent growth of prostate cancer PC-3 cells in vitro (IC50 = 12.5 µM).


References

1. Grandy, David., et al., 2009. Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. The Journal of biological chemistry. 284(24): 16256-63. PMID: 19383605

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at -20° C
IC50 :
Wnt pathway-dependent growth of prostate cancer PC-3 cells : IC50 = 12.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5221450
SMILES :
C1=CC=C(C=C1)CC(=O)NC2=CC=CC(=C2)C(=O)NC3=CC=CC=C3C(=O)O

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Certificate of Analysis

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