BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor. Phosphorylation of AMPK occurs in vivo when energy sources are low and in-turn suppress expression of SREBP-1. SREBP-1 is a key lipogenic transcription factor, and suppression of it allows glucose production by hepatocytes. In mouse studies it has been reported that BML-275 rapidly reduces the level of the phosphorylated AMPK α subunit in the hypothalamus, in an ATP-competitive manner, therefore altering energy perception and affecting the physiological energy sensor of the body. Over-activation of AMPK has also been found to be deleterious in ischemic stroke conditions and inhibition of AMPK by BML-275 may provide a small level of neuroprotection. Additional research on zebrafish has shown that BML-275 also inhibits bone morphogenetic protein signals required for iron metabolism and embryogenesis. BML-275 is also known as Dorsomorphin, Compound C, and 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine.
1. Zhou, G., et al. 2001. J. Clin. Invest. 108: 1167-1174. PMID: 11602624
2. Kim, E.K., et al. 2004. J. Biol. Chem. 279: 19970-19976. PMID: 15028725
3. McCullough, L.D., et al., 2005. J. Biol. Chem. 280: 20493-20502. PMID: 15772080
4. Ramamurthy, S. and Ronnett, G.V. 2006. J. Physiol. 574: 85-93. PMID: 16690704
5. Yu, P.B., et al. 2008. Nat. Chem. Biol. 4: 33-41. PMID: 18026094
See how others have used BML-275 (CAS 866405-64-3). Click on the entry to view the PubMed entry .
PMID: # 31038133 Zhao, Y.|Zhou, Y.|Wang, M.| et al. 2019. Food Funct.
PMID: # 30816566 Lee, SI.|Roney, MSI.|Park, JH.|Baek, JY.|Park, J.|Kim, SK.|Park, SK.| et al. 2019. Prostate. 79: 720-731.
PMID: # 29529605 Li, L.|He, M.|Xiao, H.|Liu, X.|Wang, K.|Zhang, Y.| et al. 2018. Cell. Physiol. Biochem. 45: 2021-2030.
PMID: # 30296594 Li, C.|Chen, K.|Jia, M.|Ding, X.|Jiang, Z.|Li, L.|Zhang, D.| et al. 2018. Biochim Biophys Acta Mol Cell Biol Lipids. 1863: 1498-1510.
PMID: # 29788929 Fan, Y. et al. 2018. BMC Cancer. 18: 581.
PMID: # 28729840 Marczenke, M. et al. 2017. Front Physiol. 8: 469.
PMID: # 28675237 Chen, J. et al. 2017. Food Funct. 8: 2425-2436.
PMID: # 28959214 Piccini, I.|Fehrmann, E.|Frank, S.|Müller, FU.|Greber, B.|Seebohm, G.| et al. 2017. Front Physiol. 8: 705.
PMID: # 27431894 Choi, JH.|Kim, SW.|Yu, R.|Yun, JW.| et al. 2017. Eur J Nutr. 56: 2329-2341.
PMID: # 26803770 Malan, D. et al. 2016. Basic Res. Cardiol. 111: 14.
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