BML-257An AKT1 translocation and HCV NS5B RdRp inhibitor

BML-257 (CAS 32387-96-5)

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Application: An AKT1 translocation and HCV NS5B RdRp inhibitor
CAS Number: 32387-96-5
Purity: >98%
Molecular Weight: 326.4
Molecular Formula: C21H14N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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BML-257 is an potent inhibitor of AKT1 translocation and has been observed to attenuate cannabinoid agonist-simulated neurosphere proliferation. AKT1 is a gene of the AKT family that encode for serine/threonine kinases. AKT1 is associated with pathways of cellular survival and has been implicated as a factor of various cancers. This product is often utilized in experiments concerning phosphoinostitide-3 kinase signaling and the PI3/AKT pathway. BML-257 also inhibits HCV (hepatitis C virus) NS5B RNA-dependent RNA polymerase (RdRp) with an IC50 value of 79 μM.


References

1. Lundholt, B.K., et al. 2005. J Biomol Screen. 10: 20-29. PMID: 15695340
2. Molina-Holgado, F., et al. 2007. Eur. J. Neurosci. 25: 629-634. PMID: 17328768

Physical State :
Solid
Solubility :
Soluble in 1:5 DMF:PBS(pH 7.2) (~0.15 mg/ml), ethanol (~0.25 mg/ml), DMF (~10 mg/ml), DMSO (~10 mg/ml), and water (1.17 mg/L) at 25° C.
Storage :
Store at -20° C
Melting Point :
292-294° C
Boiling Point :
~493.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.69
IC50 :
RNA-dependent RNA polymerase (RdRp): IC50 = 79 µM (hepatitis C virus (HCV) )
pK Values :
pKa: 3.18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
629852
MDL Number :
MFCD00555042
SMILES :
C1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)C(=O)O)N=C2C4=CC=CC=C4

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Certificate of Analysis

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BML-257  Product Citations

See how others have used BML-257. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30816566  Lee, SI.|Roney, MSI.|Park, JH.|Baek, JY.|Park, J.|Kim, SK.|Park, SK.| et al. 2019. Prostate. 79: 720-731.

PMID: # 25786691  Dong, G. et al. 2015. J. Immunol. 194: 3745-55.

Citations 1 to 2 of 2 total
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