BML-210An inhibitor of HDAC activity and gene expression modulator

BML-210 (CAS 537034-17-6)

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Synonym: N1-(2-aminophenyl)-N8-phenyl-octanediamide
Application: An inhibitor of HDAC activity and gene expression modulator
CAS Number: 537034-17-6
Purity: ≥98%
Molecular Weight: 339.43
Molecular Formula: C20H25N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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BML-210 has been shown to inhibit HDAC activity in HeLa nuclear extracts (IC50 = 5-10μM). Furthermore this compound was shown to inhibit growth, stimulate differentiation, and induce apoptosis in several human leukemia cell lines. These effects have been attributed to modulation of histone acetylation levels and subsequent changes in gene expression.


References

1. Herman, David., et al., 2006. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nature chemical biology. 2(10): 551-8. PMID: 16921367
2. Savickiene, Jurate., et al., 2006. The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. European journal of pharmacology. 549(1-3): 9-18. PMID: 16978604

Physical State :
Solid
Solubility :
Soluble in DMSO:PBS (pH7.2) (1:1), 100% ethanol (10 mg/ml,warm), DMF (30 mg/ml), water (0.5 mg/ml) at 25° C, and DMSO (25 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.63
IC50 :
HDAC: IC50 = 5-10 µm (HeLa cell nuclear extracts)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9543540
MDL Number :
MFCD08062139
SMILES :
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NC2=CC=CC=C2N

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Certificate of Analysis

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