BKM120CAS: 944396-07-0
MF: C18H21F3N6O2
MW: 410.39
A PI 3-kinase family inhibitor.

BKM120 (CAS 944396-07-0)

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Synonym: NVP-BKM120; Buparlisib; 5-(2,6-di-4-Morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine
Application: A PI 3-kinase family inhibitor
CAS Number: 944396-07-0
Purity: ≥98%
Molecular Weight: 410.39
Molecular Formula: C18H21F3N6O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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BKM120 is a potent and cell permeable inhibitor of the PI 3-kinase family. Specifically inhibits p110α, p110β, p110γ and p110δ with IC50 of 52 nM, 166 nM, 262 nM and 116 nM, respectively.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml), DMSO (82 mg/ml), and ethanol (2 mg/ml).
Storage :
Store at -20° C
Melting Point :
218.91° C (Predicted)
Boiling Point :
580.70-710.70° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
p110δ: IC50 = 116 nM; p110β: IC50 = 166 nM; p110γ: IC50 = 262 nM; p110α: IC50 = 52-99 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16654980
MDL Number :
MFCD18251596
SMILES :
C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

Download SDS (MSDS)

Certificate of Analysis

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BKM120  Product Citations

See how others have used BKM120. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 31119683  Tsuboi, K.|Uematsu, C.|Yamaguchi, Y.|Niwa, T.|Hayashi, SI.| et al. 2019. Breast Cancer.

PMID: # 25902041  Huang, C. et al. 2015. Int. J. Mol. Med. 36: 239-48.

PMID: # 25760103  You, Y. et al. 2015. Mol Med Rep. 12: 255-60.

PMID: # 26297436  Jung, IH. et al. 2015. Neoplasia. 17: 586-97.

PMID: # 25323007  Wang, J. et al. 2014. Oncol. Rep. 32: 2557-63.

PMID: # 25245332  Wu, L. et al. 2014. Tumour Biol. 35: 12327-37.

PMID: # 23924390  Fekete, A. et al. 2013. Journal of molecular signaling. 8: 8.

Citations 1 to 7 of 7 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. BKM120, sc-364437, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-05-05

What is the desired solvent of this chemical?

Asked by: two2igm05
Thanks for your question. BKM120, sc-364437, is soluble in DMSO at 82 mg/mL (199 mM), Water at &lt;1 mg/mL (&lt;1 mM), and Ethanol at 2 mg/mL (4 mM).
Answered by: TechService7
Date published: 2016-12-15
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