Bisindolylmaleimide VIII is a selective PKC (protein kinase C) inhibitor, with observed binding activity to dystrophia myotonica protein kinase (DMPK). Bisindolylmaleimide VIII is suggested as being slightly more specific for PKC α over PKC β, PKC γ, and PKC ε isozymes (IC50 = 53, 195, 213, and 275 respectively). The compound has been shown to improve DR5-mediated apoptosis through the MKK4/JNK/p38 kinase. When bisindolylmaleimide VIII is combined with TRA-8 it can activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase. Studies have shown that bisindolylmaleimide VIII enhance Fas-mediated apoptosis in both human astrocytoma 1321N1 cells and in Molt-4T cells.
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See how others have used Bisindolylmaleimide VIII. Click on the entry to view the PubMed entry .
PMID: # 25355318 Wang, Y. et al. 2014. The Journal of biological chemistry. 289: 35795-805.
PMID: # 22847994 2013. J Biomed Mater Res A. 101: 378-84.
PMID: # 19309729 Elkins, JM. et al. 2009. Protein Sci. 18: 782-791.
PMID: # 16352573 Park, R. et al. 2006. J. Virol. 80: 495-504.
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