BIS-Tris PropaneCAS: 64431-96-5
MF: C11H26N2O6
MW: 282.4
A buffer that is useful in the pH 6.3-9.5 range.

BIS-Tris Propane (CAS 64431-96-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 60ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 1,3-bis[tris(Hydroxymethyl)methylamino]propane
Application: A buffer that is useful in the pH 6.3-9.5 range
CAS Number: 64431-96-5
Purity: ≥99%
Molecular Weight: 282.4
Molecular Formula: C11H26N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

BIS-Tris Propane is a buffer that is useful in the pH 6.3 - 9.5 range. This wide buffering range is due to its two pKa values, 6.8 (pKa1) and 9.0 (pKa2), being so close. Because of the wide buffering range, particularly down to pH 6 - 7, this buffer has been used to enhance the stability or activity of restriction enzymes, compared to Tris buffer (which is a poor buffer below pH 7.5 and has a comparatively large change in pKa with temperature).


References

1. Weber, R. E. 1985. J Appl Physiol. 72(4): 1611-1615. PMID: 1592755

2. Eckert, K. A. and Kunkel, T. A. 1991. PCR Methods Appl. 1(1): 17-24. PMID: 1842916

3. Larsen, T. H., Et al. 2009. Macromolecules. 42(21): 8443-8450. PMID: 20161466

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (428 mg/ml).
Storage :
Store at room temperature
Melting Point :
164-165° C (lit.)
Boiling Point :
~573.32° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
pK Values :
pKa (25° C): pK1: 6.8, pK2: 9.0, pKb: 7.79 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
125132
MDL Number :
MFCD00004689
EC Number :
264-899-3
Beilstein Registry :
1786109
SMILES :
C(CNC(CO)(CO)CO)CNC(CO)(CO)CO

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

I am learning about good buffers. This buffer has been listed as a zwitterionic buffer in many places. Your site is the only one ive seen, to list it as non-zwitterionic. Please advise.

Asked by: csquare
Thank you for your question. Thank you for noticing this error on our site, we have fixed this information. This buffer is zwitterionic.
Answered by: Tech Service
Date published: 2019-09-12
  • y_2019, m_12, d_12, h_24CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.3
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_216089, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 203ms
  • QUESTIONS, PRODUCT
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.