(-)-Bicuculline methobromide CAS: 73604-30-5
MF: C21H20BrNO6
MW: 462.29
An N-methylated derivative of the GABAA antagonist bicuculline.

(-)-Bicuculline methobromide (CAS 73604-30-5)

(-)-Bicuculline methobromide | CAS 73604-30-5 is rated 5.0 out of 5 by 1.
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Application: (−)-Bicuculline methobromide is an N-methylated derivative of the GABAA antagonist bicuculline
CAS Number: 73604-30-5
Purity: ≥98%
Molecular Weight: 462.29
Molecular Formula: C21H20BrNO6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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(-)-Bicuculline methobromide is the N-methyl methobromide salt of bicuculline, a competitive antagonist of the GABAA receptor. The N-methyl derivatives (-)-Bicuculline methobromide and (-)-Bicuculline methiodide (sc-200485) are more water-soluble and stable than the parent compound and have been employed as specific GABAA receptor antagonists analogous in function to the free base of bicuculline. Non-GABAA-specific behavior divergent from the activity of the parent compound has been reported with (-)-Bicuculline methobromide and (-)-Bicuculline methiodide. Both compounds are observed to block afterhyperpolarizations mediated by Ca2+-activated K+ channels in dopaminergic neurons.


References

1. Hill, D.R. and Bowery, N.G. 1981. Nature. 290: 149-152. PMID: 6259535
2. Seutin, V., et al. 1999. Trends Pharmacol. Sci. 20: 268-270. PMID: 10390643

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), chloroform, and ethanol.
Storage :
Store at -20° C
Melting Point :
227-230° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
SMILES :
C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[Br-]

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Certificate of Analysis

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(-)-Bicuculline methobromide (CAS 73604-30-5)  Product Citations

See how others have used (-)-Bicuculline methobromide (CAS 73604-30-5). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30689790  den Boon, FS.|de Vries, T.|Baelde, M.|Joëls, M.|Karst, H.| et al. 2019. Endocrinology. 160: 791-802.

PMID: # 27460963  Karst, H.|Joëls, M.| et al. 2016. Neuropharmacology. 110: 175-180.

PMID: # 32882227  Neuropharmacology. 108294.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Luo et al Luo et al. (PubMed ID 23045343) used (-)-Bicuculline methobromide as a GABAA receptor antagonist to study GABA-mediated effects on striatal neurons. -SCBT Publication Review
Date published: 2015-02-09
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