Bicine is a zwitterionic amino acid buffer, active in the pH 7.6-9.0 range (pKa of 8.26 at 25°C). Recommended buffer for low temperature biochemical work. Bicine is used for the preparation of stable substrate solution for serum guanase determination. The use of bicine in a thin layer ion exchange chromatography method for protein resolution has been published. Bicine has been utilized in peptide and protein crystallization. A kinetic study of a quaternary transition-state analogue complex of creatine kinase used bicine in the reaction buffer. A multiphasic buffer system for SDS-PAGE of proteins and peptides that incorporates bicine has been described.
1. D.L. Williams-Smith Biochem. J. 167, 593, (1977) 2. S. Ito Clin. Chim. Acta 115, 135, (1981) 3. M. Bier, A. Kopwillem Electrochim. Acta Berlin, Ger. , 567, (1976)
Soluble in water (1M) at 20° C, ethanol (slightly), ether (slightly), and chloroform (slightly).
Store at room temperature
190° C (dec.)
361.5-415.5° C at 760 mmHg (Predicted)
1.31 g/cm3 (Predicted)
pKa: 8.4, at 20°C; pK2: 8.35 0.1M - 20°C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
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Rated 5 out of
Great!It arrived on time for when we needed to use it and we had a discount because of buying 2kg at a time!
Date published: 2019-11-12
Rated 5 out of
Various publications cite the use of bicineVarious publications cite the use of bicine as a part of a zwitterionic amino acid buffer used for work at low temperatures. -SCBT Publication Review
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