BIBR 1532A selective telomerase inhibitor

BIBR 1532 (CAS 321674-73-1)

BIBR 1532 | CAS 321674-73-1 is rated 5.0 out of 5 by 1.
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Synonym: (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
Application: A selective telomerase inhibitor
CAS Number: 321674-73-1
Purity: ≥98%
Molecular Weight: 331.37
Molecular Formula: C21H17NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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BIBR 1532 is a compound suggested to act as a selective and specific TERT (telomerase) inhibitor. Studies indicate that BIBR 1532 inhibits the TERT (reverse transcriptase of telomerase, hTERT), and shortens the length of the telomere. In addition, reports indicate that BIBR 1532 has the ability to stop cell proliferation in lung cancer cell studies after 120 days.


References

1. Damm, K., et al. 2001. EMBO J. 20: 6958-6968. PMID: 11742973
2. Barma, D.K., et al. 2003. Bioorg. Med. Chem. Lett. 13: 1333-1336. PMID: 12657276
3. Phatak, P. and Burger, A.M. 2007. Br. J. Pharmacol. 152: 1003-1011. PMID: 17603541
4. Rankin, A.M., et al. 2008. Anticancer Drugs. 19: 329-338. PMID: 18454043
5. Parsch, D., et al. 2008. Cancer Invest. 26: 590-596. PMID: 18584350

Physical State :
Solid
Solubility :
Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Storage :
Store at room temperature
Melting Point :
243.91° C (Predicted)
Boiling Point :
~600.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9927531
SMILES :
C/C(=C\\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2

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Certificate of Analysis

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BIBR 1532  Product Citations

See how others have used BIBR 1532. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29290468  Margalef, P. et al. 2018. Cell. 172: 439-453.e14.

PMID: # 24097987  Nakashima, M. et al. 2013. J. Biol. Chem. 288: 33171-80.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Bashash Bashash, D. et al. (PubMed 23293885) found that BIBR 1532, a selective telomerase inhibitor, increases arsenic trioxide-mediated apoptosis in acute promyelocytic leukemia cells. -SCBT Publication Review
Date published: 2015-04-30
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