L, from Santa Cruz. Purity: ≥90%, Molecular Formula: C15H15NO3S2, Molecular Weight: 321.41">
BH3I-1"A pro-apoptotic inhibitor of Bcl-XL

BH3I-1"

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Synonym: 2-(5-Benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)-3-methylbutanoic acid
Application: A pro-apoptotic inhibitor of Bcl-XL
Purity: ≥90%
Molecular Weight: 321.41
Molecular Formula: C15H15NO3S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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BH3I-1" is a cell permeable BH3 mimetic that binds to and inhibits Bcl-XL. BH3I-1" specifically prevents BH3 domain-mediated protein-protein interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family (Ki = 12.5 μM) by binding to the hydrophobic cleft on the surface of Bcl-XL, thereby inducing apoptosis independent of Bcl-XL pore formation.

Physical State :
Solid
Solubility :
Soluble in DMSO, and 100%ethanol.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5717719
MDL Number :
MFCD04974158
SMILES :
CC(C)C(C(=O)O)N1C(=O)/C(=C/C2=CC=CC=C2)/SC1=S

Download SDS (MSDS)

Certificate of Analysis

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