L, from Santa Cruz. Purity: ≥90%, Molecular Formula: C15H15NO3S2, Molecular Weight: 321.41">
BH3I-1" is a cell permeable BH3 mimetic that binds to and inhibits Bcl-XL. BH3I-1" specifically prevents BH3 domain-mediated protein-protein interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family (Ki = 12.5 μM) by binding to the hydrophobic cleft on the surface of Bcl-XL, thereby inducing apoptosis independent of Bcl-XL pore formation.
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