BezafibrateA peroxisome proliferator and hypolipidaemic agent

Bezafibrate (CAS 41859-67-0)

Bezafibrate | CAS 41859-67-0 is rated 5.0 out of 5 by 1.
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Synonym: Cedur
Application: A peroxisome proliferator and hypolipidaemic agent
CAS Number: 41859-67-0
Purity: ≥98%
Molecular Weight: 361.82
Molecular Formula: C19H20ClNO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bezafibrate is a peroxisome proliferator and hypolipidaemic agent that is a derivative of clofibrate. Shown to be effective in preventing mammary tumors induced by radiation together with DES, possibly by reducing prolactin and triglyceride concentrations. Bezafibrate is an activator of PPARα, PPARβ, PPARγ and LPL.


References

Inano H, Suzuki K, Wakabayashi K. Carcinogenesis. 17:2641-6 (1996). Goll V, Viollon-Abadie C, Nicod L et al. Hum Exp Toxicol. 19:193-202 (2000).

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), water (partly), methanol, ethanol (~3 mg/ml), and DMF (~30 mg/ml).
Storage :
Store at -20° C
Melting Point :
183-186° C
Boiling Point :
572.10° C at 760 mmHg (Predicted)
Density :
1.26 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
PPARβ: EC5050 = 20 µM (human); PPARα: EC5050 = 50 µM (human); PPARγ: EC5050 = 60 µM (human)
Ki Data :
I-FABP: Ki= 33 µM (human); Fatty acid-binding protein, live: Ki= 44.4 µM (rat)
pK Values :
pKa: 3.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
UE8755000
PubChem CID :
39042
Merck Index :
14: 1195
MDL Number :
MFCD00078970
EC Number :
255-567-9
Beilstein Registry :
4267656
SMILES :
CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl

Download SDS (MSDS)

Certificate of Analysis

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Bezafibrate  Product Citations

See how others have used Bezafibrate. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24140341  McIntosh, AL. et al. 2013. FEBS Lett. 587: 3787-91.

PMID: # 23747828  Petrescu, AD. et al. 2013. Biochim. Biophys. Acta. 1831: 1412-25.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Noe Noe, N. et al. (PubMed 23261681) reported that Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy. -SCBT Publication Review
Date published: 2015-05-30
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