Bexarotene is a selective RXR (retinoid X receptor) agonist used as an antineoplastic. Bexarotene is an activator of RXR α, RXR β and RXR γ.
Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994), Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996), Mukherjee, R., et al.: Nature, 386, 407 (1997), Miller, V.A., et al.: J. Clin. Oncol., 15, 790 (1997)
Soluble in methanol, DMF (20 mg/ml), DMSO (50 mg/ml), water (<1 mg/ml at 25° C), and ethanol (25 mM).
Rated 5 out of
RianchoRiancho, J. et al. (PubMed 26190974) found that Bexarotene, a selective retinoid X receptor (RXR) agonist, exhibited a neuroprotective effect in SOD1(G93A) mouse models of ALS. -SCBT Publication Review
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