BetamethasoneA glucocorticoid that induces gene expression and apoptosis

Betamethasone (CAS 378-44-9)

Betamethasone | CAS 378-44-9 is rated 5.0 out of 5 by 1.
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Synonym: Becort; Celestene; Flubenisolone
Application: A glucocorticoid that induces gene expression and apoptosis
CAS Number: 378-44-9
Purity: ≥98%
Molecular Weight: 392.46
Molecular Formula: C22H29FO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Betamethasone is a glucocorticoid that induces gene expression and apoptosis. Betamethasone is an activates the glucocorticoid receptor (GR).


References

Kalthoff FS, Chung J, Musser P et al. Clin Exp Immunol. 133:350-9 (2003). Hofmann TG, Hehner SP, Bacher S et al. FEBS Lett. 441:441-6 (1998).

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in alcohol (1:75), methanol, DMSO (79 mg/ml at 25° C), and ethanol (10 mg/ml at 25° C). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
235-237° C (lit.)
Boiling Point :
568.23° C at 760 mmHg (Predicted)
Density :
1.33 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20/D +118°±3°, c = 1 in Dioxane
IC50 :
GR: IC50 = 7.74 nM (human); Plasmodium falciparum GB4 : IC50 = 12.59 µM; Plasmodium falciparum W2 : IC50 = 12.59 µM; Plasmodium falciparum HB3: IC50 = 15.85 µM
Ki Data :
GR: Ki= 3.52 nM (human)
pK Values :
pKa: 12.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TU4000000
PubChem CID :
9782
Merck Index :
14: 1180
MDL Number :
MFCD00062969
EC Number :
206-825-4
Beilstein Registry :
3176546
SMILES :
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Neuhaus et al Neuhaus et al. (PubMed ID 262748418) showed that the gluccocorticoid, betamethasone, had adverse effects on brain development in newborn mouse pups. -SCBT Publication Review
Date published: 2015-04-24
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