beta-SitosterolA plant steroid which induces G2/M arrest

β-Sitosterol (CAS 83-46-5)

β-Sitosterol | CAS 83-46-5 is rated 5.0 out of 5 by 1.
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Synonym: α-Dihydrofucosterol, 22,23-Dihydrostigmasterol; α-Phytosterol; SITO
Application: A plant steroid which induces G2/M arrest
CAS Number: 83-46-5
Molecular Weight: 414.7
Molecular Formula: C29H50O
* Refer to Certificate of Analysis for lot specific data (including water content).
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β-Sitosterol is a common plant steroid that possesses anticholesteremic properties. β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.


References

Moon, D., et al. 2008. Cancer Lett. 264, 181.

Appearance :
Powder
Physical State :
Solid
Derived From :
Soybeans
Solubility :
Soluble in water (partly miscible).
Storage :
Store at 4° C
Melting Point :
136-140° C (lit.)
Boiling Point :
501.95° C at 760 mmHg (Predicted)
Density :
0.98 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
A2780: IC50 = >10 ug/ml (human); Bel-7402: IC50 = >10 ug/ml (human); A549: IC50 = >10 ug/ml (human); BGC-823: IC50 = >10 ug/ml (human); HCT-8: IC50 = >10 ug/ml (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WJ2600000
PubChem CID :
222284
Merck Index :
14: 8556
MDL Number :
MFCD00003631
EC Number :
201-480-6
Beilstein Registry :
1916165
SMILES :
CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C

Download SDS (MSDS)

Certificate of Analysis

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beta-Sitosterol  Product Citations

See how others have used beta-Sitosterol. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25973984  Leal-Castañeda, EJ. et al. 2015. Journal of agricultural and food chemistry. 63: 5539-47.

PMID: # 25262005  Kim, KS. et al. 2014. BMC Complement Altern Med. 14: 363.

PMID: # 24628700  2014. J. Agric. Food Chem.

Citations 1 to 3 of 3 total

I am comparing your Beta-Sitosterol to a similar product from Sigma-Aldrich, S9889 Sigma. There is a large difference in price and quantity. Is the SantaCruz product similar in purity?

Asked by: Michael Lyons
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26
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Rated 5 out of 5 by from Styrczewska et al Styrczewska et al. (PubMed ID 26347154) found that -Sitosterol acted synergistically with CBD to reduce cytokine expression. -SCBT Publication Review
Date published: 2015-04-24
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