β-Secretase Inhibitor IV, a cell-permeable isophthalamide compound containing a hydroxyethylamine motif which binds to BACE-1 active site and potently blocks its proteolytic activity. The compound displays greater selectivity over other aspartyl proteases. β-Secretase Inhibitor IV is an inhibitor of BACE and BACE2.
Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo_sdk, java_sdk, bvseo-3.2.0
CLOUD, getContent, 105ms
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
JiaranaikulwanitchJiaranaikulwanitch, J. et al. (PubMed 22781443) modified the tryptoline and tryptamine cores of BACE1 inhibitors previously identified by virtual screening in silico for additional modes of action. These core structures were readily linked to different side chains using 1,2,3-triazole rings as bridges by copper catalyzed azide-alkyne cycloaddition reactions. The neuroprotective effects of the multifunctional compounds 6h, 12c and 12h on A induced neuronal cell death at 1 M were significantly greater than those of the potent single target compound, BACE1 inhibitor IV and were comparable to curcumin. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.