beta-Estradiol CAS: 50-28-2
MF: C18H24O2
MW: 272.38
An ER agonist and activator of PI 3-kinase.

β-Estradiol (CAS 50-28-2)

β-Estradiol | CAS 50-28-2 is rated 5.0 out of 5 by 1.
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Alternate Names: 17β-Estradiol; 17β-Oestradiol; E2; Estradiol; 1,3,5-Estratriene-3,17β-diol
Application: β-Estradiol is an ER agonist and activator of PI 3-kinase
CAS Number: 50-28-2
Purity: ≥98%
Molecular Weight: 272.38
Molecular Formula: C18H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.


References

Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and b. Endocrinology 138 863. Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146 624.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (75 mM), Dimethylsulfoxide, water (<1 mg/mL), 1:4 solution of DMSO:PBS(pH=7.2) (0.2 mg/mL), DMF, acetone, dioxane, solutions of fixed alkali hydroxides, and vegetable oils (sparingly).
Storage :
Store at room temperature
Melting Point :
176-180° C (lit.)
Boiling Point :
~445.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Optical Activity :
α20/D +76.8°, c = 1 in Dioxane
IC50 :
Estrogen receptor: IC50 = 0.01 nM (human); SK-BR-3: IC50 = 0.1 nM (human); MCF7: IC50 = 0.32 nM (human); ERα : IC50 = 0.57 nM (human)
Ki Data :
ERα : Ki= 0.12 nM (human); ERβ : Ki= 0.13 nM (human)
pK Values :
pKa: 10.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KG2975000
PubChem CID :
Merck Index :
14: 3703
MDL Number :
MFCD00003693
EC Number :
200-023-8
Beilstein Registry :
1914275

Download SDS (MSDS)

Certificate of Analysis

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beta-Estradiol (CAS 50-28-2)  Product Citations

See how others have used beta-Estradiol (CAS 50-28-2). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30542051  Choi, HJ.|Chung, TW.|Choi, HJ.|Han, JH.|Choi, JH.|Kim, CH.|Ha, KT.| et al. 2018. Exp Mol Med. 50: 1-12.

PMID: # 27605343  Chen, CD. et al. 2016. Biol. Reprod.

PMID: # 27907195  Hanieh, H. et al. 2016. PLoS ONE. 11: e0167650.

PMID: # 24747804  Cheng, X. et al. 2014. Toxicology and applied pharmacology. 278: 78-84.

PMID: # 32932770  Cells.

PMID: # 32983995  1509.

Citations 1 to 6 of 6 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. We recommend using an organic solvent purged with an inert gas. Solubility in an organic solvent such as ethanol, DMSO or DMF is at least 2.5 mg/ml. This compound is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, the compound should be first dissolved in an organic solvent such as DMSO and then diluted with water. We do not recommend storing in aqueous solutions for more than one day. Great care should be taken to make sure that the organic solvent does not have physiological effects on the experiment. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2020-11-12
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Rated 5 out of 5 by from Ikeda Ikeda, M. et al. (PubMed 26384003) investigated wether male and aged female mice would benefit from estrogen administration after cardiac arrest and cardiopulmonary resuscitation (CA/CPR). Post-arrest estrogen administration, using -Estradiol, reduced serum creatinine (sCr) and volume of necrotic tubules (VNT) in young males compared to no affect in young female mice. In aged mice, estrogen significantly reduced sCr and VNT in males and VNT in females. -SCBT Publication Review
Date published: 2015-05-12
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