Bestatin Methyl EsterAn aminopeptidase inhibitor

Bestatin Methyl Ester (CAS 65322-89-6)

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Application: An aminopeptidase inhibitor
CAS Number: 65322-89-6
Purity: ≥97%
Molecular Weight: 322.4
Molecular Formula: C17H26N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bestatin methyl ester is a cell-permeable derivative of Bestatin which displays slightly stronger inhibition of neutral aminopeptidase than Bestatin, but has much weaker activity against basic aminopeptidase. Bestatin methyl ester also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.


References

Sekine, K., et al. 2001. Int. J. Cancer 94, 485.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).Unstable in aqueous solution; dilute just prior to use
Storage :
Store at 4° C
Melting Point :
202.81° C (Predicted)
Boiling Point :
535.05° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
IC50 :
neutral amino pepsidase: IC50 = 31.6 nM; basic amino peptidase : IC50 = 400 nM; c-IAP1: IC50 = 690 nM (human)
pK Values :
pKa: 10.88 (Predicted), 6.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9927170
MDL Number :
MFCD04974144
SMILES :
CC(C)C[C@@H](C(=O)OC)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O

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Certificate of Analysis

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Bestatin Methyl Ester  Product Citations

See how others have used Bestatin Methyl Ester. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22345351  Poloz, Y. et al. 2012. Eukaryotic Cell. 11: 545-557.

Citations 1 to 1 of 1 total
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