Bestatin hydrochlorideAn inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase

Bestatin hydrochloride (CAS 65391-42-6)

Bestatin hydrochloride | CAS 65391-42-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_9, d_23, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200564, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 145ms
  • REVIEWS, PRODUCT
Synonym: N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride;[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine . HCl
Application: An inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase
CAS Number: 65391-42-6
Purity: ≥98%
Molecular Weight: 344.83
Molecular Formula: C16H24N2O4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.


References

1. Rich, D.H., et al. 1984. J. Med. Chem. 27: 417-422. PMID: 6142952
2. Wilkes, S.H. and Prescott, J.M. 1985. J. Biol. Chem. 260: 13154-13162. PMID: 2865258
3. Orning, L., et al. 1991. J. Biol. Chem. 266: 1375-1378. PMID: 1846352
4. Taylor, A. 1993. FASEB J. 7: 290-298. PMID: 8440407

Physical State :
Solid
Solubility :
Soluble in water (4 mg/ml,warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
216° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11957481
MDL Number :
MFCD00058004
Beilstein Registry :
4628066
SMILES :
CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Bestatin hydrochloride  Product Citations

See how others have used Bestatin hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25042057  Kong, L. et al. 2015. Arch. Insect Biochem. Physiol. 88: 64-84.

Citations 1 to 1 of 1 total

How long are stock solutions stable for?

Asked by: SCchem16
Thank you for your question. This chemical, Bestatin hydrochloride (CAS 65391-42-6), is stable for 1 month at -20°C in organic solvents. We do not recommend storing aqueous solutions for more than one day.
Answered by: Chemical Support 2
Date published: 2017-03-02
  • y_2019, m_9, d_23, h_9CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_200564, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 83ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Trochine Trochine, A. et al. (PubMed 25712359) reported that Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool. -SCBT Publication Review
Date published: 2015-06-11
  • y_2019, m_9, d_23, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200564, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.