Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.
1. Rich, D.H., et al. 1984. J. Med. Chem. 27: 417-422. PMID: 6142952 2. Wilkes, S.H. and Prescott, J.M. 1985. J. Biol. Chem. 260: 13154-13162. PMID: 2865258 3. Orning, L., et al. 1991. J. Biol. Chem. 266: 1375-1378. PMID: 1846352 4. Taylor, A. 1993. FASEB J. 7: 290-298. PMID: 8440407
Soluble in water (4 mg/ml,warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Thank you for your question. This chemical, Bestatin hydrochloride (CAS 65391-42-6), is stable for 1 month at -20°C in organic solvents. We do not recommend storing aqueous solutions for more than one day.
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