Berberine hydrochlorideAn isoquinoline alkaloid

Berberine hydrochloride (CAS 633-65-8)

Berberine hydrochloride | CAS 633-65-8 is rated 4.0 out of 5 by 1.
  • y_2019, m_9, d_17, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204645, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 144ms
  • REVIEWS, PRODUCT
Synonym: Natural Yellow 18; Berberinium chloride; BBR; Umbellatine
Application: An isoquinoline alkaloid
CAS Number: 633-65-8
Purity: >95%
Molecular Weight: 371.81
Molecular Formula: C20H17NO4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis.


References

Fukuda K., Hibiya Y., Mutoh M., Koshiji M., Akao s., Fujiwara H. J. Ethno. 66:227-33 (1999).

Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
193-196° C (dec.)
IC50 :
AChE: IC50 = 40 nM (human); Plasmodium falciparum D6: IC50 = 0.14 ug.mL-1; Plasmodium falciparum W2: IC50 = 0.15 ug.mL-1; Plasmodium falciparum K1: IC50 = 0.36 ug.mL-1; SrtA: IC50 = 8.7 ug.mL-1 (Staphylococcus aureus subsp. aureus N315)
Ki Data :
α2B-AR: Ki= 274 nM (human); Acetylcholinesterase: Ki= 289 nM (Electrophorus electricus); Serotonin 4 (5-HT4) receptor: Ki= 370 nM (Cavia porcellus); α2C-AR: Ki= 412 nM (human); σReceptor: Ki= 542 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DR9866400
PubChem CID :
12456
Merck Index :
14: 1154
MDL Number :
MFCD00011939
EC Number :
211-195-9
Beilstein Registry :
3836585
SMILES :
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 157ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
  • y_2019, m_9, d_17, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204645, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 24ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.