Berberine hemisulfateAn alkaloid compound with anti-inflammatory activity that fluoresces under ultraviolet light

Berberine hemisulfate (CAS 633-66-9)

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Application: An alkaloid compound with anti-inflammatory activity that fluoresces under ultraviolet light
CAS Number: 633-66-9
Molecular Weight: 384.4
Molecular Formula: C20H18NO41/2SO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Berberine Hemisulfate is an alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects. Induces apoptosis.


References

1. Kuo, C.L., et al. 2004. Cancer Lett. 203: 127-137. PMID: 14732220
2. Yin, J., et al. 2008. Endocr Metab Immune Disord Drug Targets. 8: 99-111. PMID: 18537696
3. Kulkarni, S.K., et al. 2008. Eur. J. Pharmacol. 589: 163-172. PMID: 18585703
4. Yin, J., et al. 2008. Metab. Clin. Exp. 57: 712-717. PMID: 18442638
5. Sun, Y., et al. 2009. Anticancer Drugs. 20: 757-769. PMID: 19704371
6. Kulkarni, S.K., et al. 2009. Expert Opin Investig Drugs. 18: 767-788. PMID: 19426122
7. Kulkarni, S.K., et al. 2009. Expert Rev Neurother. 9: 1021-1034. PMID: 19589051
8. Tang, J., et al. 2009. J Ethnopharmacol. 126: 5-17. PMID: 19686830
9. Sarna, L.K, et al. 2010. Can. J. Physiol. Pharmacol. 88: 369-378. PMID: 20393601
10. Zhang, H., et al. 2010. Metab. Clin. Exp. 59: 285-292. PMID: 19800084
11. Zha, W., et al. 2010. PLoS ONE. 5: e9069. PMID: 20161729
12. Kulkarni, S.K., et al. 2010. Phytother Res. 24: 317-324. PMID: 19998323
13. Choi, B.H., et al. 2009. Nutr Res Pract. 3: 84-88. PMID: 20016706

Appearance :
Powder
Physical State :
Solid
Derived From :
Hydrastis canadensis L., Berberidaceae
Solubility :
50mg/ml soluble in methanol:water 2:1.
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
COc1c(OC)ccc2cc3[n+](CCc4cc5OCOc5cc34)cc12

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Certificate of Analysis

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What standard was used to determine the purity of the prduct? HPLC or other means? Thank you

Asked by: LolaFF
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26
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