BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator. This protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PKR is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of ATF-3, p53, eIF2α and NF-κB. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.
Hu, W., et al., Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J. Pharmacol. Exp. Ther. 328, 866-872, (2009)
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.