BEPP monohydrochloride (CAS 455311-98-5)

BEPP monohydrochloride serves as an activator of double-strand RNA-dependent PKR (protein kinase), an essential serine threonine kinase that is ubiquitously expressed and inducible by interferon γ. PKR plays a pivotal role in various cellular regulations, including the phosphorylation of eIF2α, which leads to protein synthesis inhibition and triggers antivirus and antitumor activities. Additionally, PKR modulates the activities of ATF-3, p53, eIF2α, and NF-κB. The growth of a human lung cancer cell line overexpressing PKR can also be inhibited by BEPP. In the realm of scientific research, BEPP monohydrochloride finds extensive applications. It serves as a model compound for exploring the reactivity of organic compounds in aqueous solutions. Moreover, it is employed in studying enzyme-catalyzed reactions and investigating lipid metabolism. The interaction between drugs and proteins, as well as the pharmacokinetics of drugs, has been further elucidated using BEPP monohydrochloride. Acting as a proton donor in aqueous solutions, BEPP monohydrochloride plays a vital role in proton transfer. By donating protons to other molecules in an aqueous environment, it facilitates the formation of new molecules. Proton transfer is an indispensable process for numerous biochemical and physiological phenomena.