Benztropine mesylateAn antagonist of the mAChR

Benztropine mesylate (CAS 132-17-2)

Benztropine mesylate | CAS 132-17-2 is rated 5.0 out of 5 by 1.
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Synonym: Benztropine methanesulfonate
Application: An antagonist of the mAChR
CAS Number: 132-17-2
Purity: ≥98%
Molecular Weight: 403.53
Molecular Formula: C21H25NO•CH4SO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Benztropine mesylate is a derivative of Atropine (sc-203322) and an antagonist of the mAChR (muscarinic acetylcholine receptor). This compound demonstrates anti-muscarinic effects comparable to Atropine, and also demonstrates competitive anti-nicotinic action at the nAChR (nicotinic acetylcholine receptor) unobserved with Atropine.


References

1. Bowers, M.B. and Roth, R.H. 1972. Br. J. Pharmacol. 44: 301-306. PMID: 4148918
2. Gao, Z.G., et al. 1998. J. Pharm. Pharmacol. 50: 1299-1305. PMID: 9877318

Physical State :
Solid
Solubility :
Soluble in water (81 mg/ml at 25° C), DMSO (50 mg/ml at 25° C), ethanol (81 mg/ml at 25° C), and ether (very slightly).
Storage :
Store at 4° C
Melting Point :
135° C (lit.)
IC50 :
dopamine transporter: IC50 = 118 nM; MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter : EC5050 = 28 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YM3150000
PubChem CID :
238053
Merck Index :
14: 1121
MDL Number :
MFCD00074784
EC Number :
205-048-8
SMILES :
CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)O

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Certificate of Analysis

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Benztropine mesylate  Product Citations

See how others have used Benztropine mesylate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26202243  Cheng, H. et al. 2015. J. Virol. 89: 9932-8.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Mingorance L; et al Mingorance L; et al. (PubMed ID: 24709263) determined that Benztropine mesylate, a Hepatitis C virus antiviral, effectively inhibited viral entry without effecting the entry of other viruses. -SCBT Publication Review
Date published: 2015-06-30
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