Benztropine mesylate is a derivative of Atropine (sc-203322) and an antagonist of the mAChR (muscarinic acetylcholine receptor). This compound demonstrates anti-muscarinic effects comparable to Atropine, and also demonstrates competitive anti-nicotinic action at the nAChR (nicotinic acetylcholine receptor) unobserved with Atropine.
1. Bowers, M.B. and Roth, R.H. 1972. Br. J. Pharmacol. 44: 301-306. PMID: 4148918 2. Gao, Z.G., et al. 1998. J. Pharm. Pharmacol. 50: 1299-1305. PMID: 9877318
Soluble in water (81 mg/ml at 25° C), DMSO (50 mg/ml at 25° C), ethanol (81 mg/ml at 25° C), and ether (very slightly).
Store at 4° C
135° C (lit.)
dopamine transporter: IC50 = 118 nM; MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter : EC5050 = 28 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Mingorance L; et alMingorance L; et al. (PubMed ID: 24709263) determined that Benztropine mesylate, a Hepatitis C virus antiviral, effectively inhibited viral entry without effecting the entry of other viruses. -SCBT Publication Review
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