Benzo[a]pyrene

Benzo[a]pyrene (CAS 50-32-8)

Benzo[a]pyrene | CAS 50-32-8 is rated 5.0 out of 5 by 1.
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Synonym: 3,4-Benzopyrene
Application: A polycyclic aromatic hydrocarbon
CAS Number: 50-32-8
Purity: ≥96%
Molecular Weight: 252.31
Molecular Formula: C20H12
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Benzo[a]pyrene is a polycyclic aromatic hydrocarbon (PAH), environmental pollutant and carcinogen. IT is employed as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on its oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.


References

1. Gamper, H.B., et al. 1980. Biochemistry. 19: 3948-3956. PMID: 6250579
2. Revel, A., et al. 2003. J Appl Toxicol. 23: 255-261. PMID: 12884409
3. Andrysík, Z., et al. 2007. Mutat. Res. 615: 87-97. PMID: 17141280
4. Operaña, T.N., et al. 2007. Toxicol. Sci. 95: 98-107. PMID: 17065433

Physical State :
Solid
Solubility :
Soluble in benzene, toluene, xylene, ethanol (sparingly soluble), methanol (sparingly soluble), and ether. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
177-180° C (lit.)
Boiling Point :
495° C (lit.)
Density :
1.35 g/cm3
Refractive Index :
n20D 1.89 (Predicted)
IC50 :
Cytochrome P450 1A2: IC50 = 40 nM (human); Monoamine oxidase A: IC50 = 5972 nM (human); Tyrosine-protein kinase FYN: IC50 = 26.2 µM (human); Acetylcholinesterase: IC50 = 28 µM (human); Receptor protein-tyrosine kinase erbB-2: IC50 = 41.5 µM (human); Aryl hydrocarbon receptor: EC5050 = 5 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DJ3675000
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
2336
Merck Index :
14: 1103
MDL Number :
MFCD00003602
EC Number :
200-028-5
Beilstein Registry :
1911333
SMILES :
C1=CC=C2C3=C4C(=CC2=C1)C=CC5=C4C(=CC=C5)C=C3

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Certificate of Analysis

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We are a research group from Universidad del Sur (Bs As, Argentine) and we are looking forward to buying Benzo(a)pirene. Does the price shown on your website includes sending? If it does not, we would appreciate if you could provide us its final cost?

Asked by: Damián
Thank you for your question. Please contact one of our authorized distributors for information about current product availability and shipping lead times.
Answered by: Technical Support
Date published: 2019-05-03
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Rated 5 out of 5 by from Various publications cite the use of Benzo[a]pyrene Various publications cite the use of Benzo[a]pyrene as a chemical carcinogen in experimental models of cancer. -SCBT Publication Review
Date published: 2015-01-04
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