Benzo[a]pyrene is a polycyclic aromatic hydrocarbon (PAH), environmental pollutant and carcinogen. IT is employed as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on its oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.
1. Gamper, H.B., et al. 1980. Biochemistry. 19: 3948-3956. PMID: 6250579 2. Revel, A., et al. 2003. J Appl Toxicol. 23: 255-261. PMID: 12884409 3. Andrysík, Z., et al. 2007. Mutat. Res. 615: 87-97. PMID: 17141280 4. Operaña, T.N., et al. 2007. Toxicol. Sci. 95: 98-107. PMID: 17065433
Soluble in benzene, toluene, xylene, ethanol (sparingly soluble), methanol (sparingly soluble), and ether. Insoluble in water.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
UN 3077, Class 9, Packing group III
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We are a research group from Universidad del Sur (Bs As, Argentine) and we are looking forward to buying Benzo(a)pirene. Does the price shown on your website includes sending? If it does not, we would appreciate if you could provide us its final cost?
Asked by: Damián
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Various publications cite the use of Benzo[a]pyreneVarious publications cite the use of Benzo[a]pyrene as a chemical carcinogen in experimental models of cancer. -SCBT Publication Review
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