Date published: 2025-10-19

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Benzarone (CAS 1477-19-6)

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CAS Number:
1477-19-6
Molecular Weight:
266.29
Molecular Formula:
C17H14O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Benzarone is a chemical compound primarily known for its application in research focused on cellular oxidative processes and its role as a selective inhibitor of xanthine oxidase, an enzyme involved in the metabolic breakdown of purines. In biochemical studies, Benzarone is employed to probe the mechanisms of enzyme inhibition and to explore the dynamics of free radical generation within biological systems. Its utility extends to the investigation of the molecular pathways that contribute to oxidative stress, which is a critical factor in the study of various cellular dysfunctions. Researchers have found Benzarone useful in examining the impact of reduced xanthine oxidase activity on cellular metabolism, as well as in the broader context of understanding the enzyme′s contribution to the production of reactive oxygen species. Additionally, Benzarone′s ability to modulate xanthine oxidase activity makes it useful in the field of enzymology and in studies related to the metabolic fate of purines.


Benzarone (CAS 1477-19-6) References

  1. [Drug-induced hepatitis due to benzarone (Fragivix): apropos of a clinical case report].  |  Sepulchre, D., et al. 1990. Acta Gastroenterol Belg. 53: 499-503. PMID: 2130580
  2. Benzarone-induced liver injury: First case report in Asia.  |  Tseng, HH., et al. 2020. J Formos Med Assoc. 119: 1445-1447. PMID: 32088095
  3. Chronic active hepatitis caused by benzarone.  |  Babany, G., et al. 1987. J Hepatol. 5: 332-5. PMID: 3429840
  4. Metabolic fate of the thrombolytic agent benzarone in man: comparison with the rat and dog.  |  Wood, SG., et al. 1987. Xenobiotica. 17: 881-96. PMID: 3660858
  5. Determination of benzarone in human plasma and urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. Identification of the conjugates.  |  de Vries, JX., et al. 1986. J Chromatogr. 382: 167-74. PMID: 3782383
  6. [The influence of benzarone on the polidocanol and thiopental induced edemas in the hind-limb of the cat (author's transl)].  |  Felix, W. 1978. Arzneimittelforschung. 28: 2300-2. PMID: 582947
  7. The effect of 2-ethyl-3-(4-hydroxybenzoyl)-benzofuran (benzarone) on the metabolism of arterial tissue and cultured arterial smooth muscle cells.  |  Filipovic, I. and Buddecke, E. 1979. Arzneimittelforschung. 29: 1578-80. PMID: 583226
  8. [Effect of benzarone on the oxygen consumption and the mechanical activity of vascular smooth muscle].  |  Knehr, HE. and Betz, E. 1983. Arzneimittelforschung. 33: 211-4. PMID: 6682659
  9. [The effect of benzarone on serum lipids and arterial wall of cholesterol fed rats].  |  Schmidt, A., et al. 1982. Arzneimittelforschung. 32: 810-5. PMID: 6890357
  10. [Influence of 2-ethyl-3-(4-hydroxybenzoyl)-benzofuran (benzarone) on experimental atheromatosis (author's transl)].  |  Roth, J., et al. 1980. Arzneimittelforschung. 30: 1897-902. PMID: 7193000
  11. Pharmacokinetics and biotransformation of benzbromarone in man.  |  Ferber, H., et al. 1981. Eur J Clin Pharmacol. 19: 431-5. PMID: 7250176
  12. Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.  |  Hautekeete, ML., et al. 1995. Liver. 15: 25-9. PMID: 7776854
  13. Subfulminant hepatitis requiring liver transplantation after benzarone administration.  |  Gehenot, M., et al. 1994. J Hepatol. 20: 842. PMID: 7930488

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Benzarone, 25 mg

sc-482112
25 mg
$91.00