BelinostatA novel HDAC inhibitor

Belinostat (CAS 414864-00-9)

Belinostat | CAS 414864-00-9 is rated 5.0 out of 5 by 1.
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Synonym: (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]acrylamide
Application: A novel HDAC inhibitor
CAS Number: 414864-00-9
Molecular Weight: 318.35
Molecular Formula: C15H14N2O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Belinostat (PXD101) is a novel HDAC (histone deacetylase) inhibitor with IC50 of 27 nM. Belinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells. Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase, and increase in G2-M phase. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines. A recent study shows that Belinostat activates PKA (protein kinase A) in a TGF-β signaling-dependent mechanism and decreases survivin mRNA. Belinostat is an inhibitor of HDAC3 (histone deacetylase 3).

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
241.16° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918638
SMILES :
C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO

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Rated 5 out of 5 by from Belinostat was reported as an anticancer Belinostat was reported as an anticancer agent and an inhibitor of HDAC3, in many articles. -SCBT Publication Review
Date published: 2015-03-18
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