BEC, HydrochlorideA competitive transition state inhibitor of arginases I and II

BEC, Hydrochloride

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Synonym: (S)-(2-Boronoethyl)-L-cysteine, HCI
Application: A competitive transition state inhibitor of arginases I and II
Purity: ≥97%
Molecular Weight: 229.5
Molecular Formula: C5H13BClNO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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BEC, Hydrochloride is a boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginase I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS), it causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.


References

Colleluori, D.M., and Ash, D.E. 2001. Biochemistry 40, 9356. Kim, N.N., et al. 2001. Biochemistry 40, 2678.

Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml).
Storage :
Store at -20° C
Ki Data :
recombinant type II arginase, pH 7.5: Ki= 310 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760311
MDL Number :
MFCD06858341
SMILES :
B(CCSC[C@H](C(=O)O)[NH3+])(O)O.[Cl-]

Download SDS (MSDS)

Certificate of Analysis

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