BEC ammonium saltCAS: 63107-40-4 (non-salt)
MF: C5H11BNO4S•NH4
MW: 210.07
A slow-binding, competitive inhibitor of arginase I and II.

BEC ammonium salt (CAS 63107-40-4 (non-salt))

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Synonym: S-(2-Boronoethyl)-L-cysteine . NH4
Application: A slow-binding, competitive inhibitor of arginase I and II
CAS Number: 63107-40-4 (non-salt)
Purity: ≥95%
Molecular Weight: 210.07
Molecular Formula: C5H11BNO4S•NH4
* Refer to Certificate of Analysis for lot specific data (including water content).

BEC ammonium salt is a slow-binding, competitive inhibitor of arginase I (Ki = 0.4-0.6 μM & KD = 2.22 μM for recombinant rat liver arginase) and arginase II (Ki = 0.31 μM at pH 7.5 and 0.03 μM at pH 9.5 for human recombinant type II arginase). BEC ammonium salt enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. BEC ammonium salt does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. BEC ammonium salt is also an inhibitor of rat aortic smooth muscle cell proliferation.


References

1. Kim, N N., et al., 2001. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 40(9): 2678-88. PMID: 11258879
2. Cox, J D., et al., 2001. Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry. 40(9): 2689-701. PMID: 11258880
3. Wei, L H., et al., 2001. Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 98(16): 9260-4. PMID: 11470919
4. Colleluori, D M., et al., 2001. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 40(31): 9356-62. PMID: 11478904
5. Berkowitz, Dan E., et al., 2003. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 108(16): 2000-6. PMID: 14517171

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.55 (Predicted)
Ki Data :
arginase II: Ki= 0.31 µM; arginase I: Ki= 0.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD08702684
SMILES :
B(CCSC[[email protected]@H](C(=O)O)N)(O)O

Download SDS (MSDS)

Certificate of Analysis

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