BECCAS: 63107-40-4
MF: C5H12BNO4S
MW: 193.02
A potent, slow-binding inhibitor of recombinant rat liver arginase I.

BEC (CAS 63107-40-4)

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Synonym: S-(2-boronoethyl)-L-cysteine
Application: A potent, slow-binding inhibitor of recombinant rat liver arginase I
CAS Number: 63107-40-4
Purity: >98%
Molecular Weight: 193.02
Molecular Formula: C5H12BNO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I (Ki = 0.4-0.6 μM), as well as human arginase II (Ki = 0.31 μM and 30 nM at pH 7.5 and 9.5, respectively), though it does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM. L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine.


References

1. Kim, N N., et al., 2001. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 40(9): 2678-88. PMID: 11258879
2. Colleluori, D M., et al., 2001. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 40(31): 9356-62. PMID: 11478904

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml at 25° C), ethanol (sparingly soluble), DMSO (sparingly soluble), DMF (sparingly soluble), and PBS, pH 7.2 (~5 mg/ml).
Storage :
Store at -20° C
Melting Point :
299.45° C (Predicted)
Boiling Point :
451.64° C at 760 mmHg (Predicted)
Density :
1.37 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Ki Data :
Arginase II: Ki= 30 nM (human) pH 9.5; Arginase II: Ki= 0.31 µM (human) pH 7.5; Liver arginase I : Ki= 0.4-0.6 µM (recombinant rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9877608
MDL Number :
MFCD08062197
SMILES :
B(CCSCC(C(=O)O)N)(O)O

Download SDS (MSDS)

Certificate of Analysis

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