Bcl-2 Inhibitor II, YC137 is a cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells. Bcl-2 Inhibitor II, YC137 preferentially binds Bcl-2 (Ki = 1.3 μM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. This has shown to induce the release of cytochrome c from mitochondria as well as activate caspase-9.
Real, P.J., et al. 2004. Cancer Res. 64, 7947.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.