Bcl-2 Inhibitor II, YC137A naphthoquinone inducer of apoptosis

Bcl-2 Inhibitor II, YC137 (CAS 810659-53-1)

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Application: A naphthoquinone inducer of apoptosis
CAS Number: 810659-53-1
Molecular Weight: 511.6
Molecular Formula: C24H21N3O6S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bcl-2 Inhibitor II, YC137 is a cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells. Bcl-2 Inhibitor II, YC137 preferentially binds Bcl-2 (Ki = 1.3 μM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. This has shown to induce the release of cytochrome c from mitochondria as well as activate caspase-9.


References

Real, P.J., et al. 2004. Cancer Res. 64, 7947.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), and methanol (5 mg/ml).
Storage :
Store at -20° C
Density :
1.44 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
Ki Data :
Bcl-2: Ki= 1.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918811
SMILES :
COC(=O)NC(CCSC)C(=O)OC1=CC=C(C=C1)NC2=NC3=C(S2)C(=O)C4=CC=CC=C4C3=O

Download SDS (MSDS)

Certificate of Analysis

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