BAY-u 3405 suppresses PGD2-induced migration of human eosinophils (IC50 = 170 nM). Potent dual antagonist of TXA2R (TP)/DP2 (CRTH2) prostanoid receptors (Ki values are 4.3, 4.5 and > 10000 nM for hDP2, hTP and hDP1 receptors respectively).
1. Sundström, Ewa., et al., 2003. Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. The Journal of pharmacology and experimental therapeutics. 307(1): 408-18. PMID: 12954791
2. Ishizuka, Toshiaki., et al., 2004. Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovascular drug reviews. 22(2): 71-90. PMID: 15179446
3. Ulven, Trond., et al., 2005. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. Journal of medicinal chemistry. 48(4): 897-900. PMID: 15715457
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