BAY 11-7082An anti-inflammatory agent and NFκB inhibitor

BAY 11-7082 (CAS 19542-67-7)

BAY 11-7082 | CAS 19542-67-7 is rated 5.0 out of 5 by 1.
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Synonym: (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile; 3- [(4- methylphenyl)sulfonyl]- (2E)- propenenitrile
Application: An anti-inflammatory agent and NFκB inhibitor
CAS Number: 19542-67-7
Purity: ≥98%
Molecular Weight: 207.25
Molecular Formula: C10H9NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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BAY 11-7082, a potential anti-inflammatory agent, is an irreversible inhibitor of IKK α and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM). In intact HUVECs, it inhibits TNFα-induced phosphorylation and degradation of IκBa (NFKBIA) without affecting constitutive phosphorylation. Inhibition of ιBα phosphorylation and degradation results in the inactivation of NFκB and thereby inhibits the expression of endothelial-leukocyte adhesion molecules: E-selectin, VCAM-1 and ICAM-11. BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1.


References

1. Pierce, J.W., et al. 1997. J. Biol. Chem. 272: 21096-21103. PMID: 9261113
2. Keller, S.A., et al. 2000. Blood. 96: 2537-2542. PMID: 11001908
3. Remacle-Bonnet, M.M., et al. 2000. Cancer Res. 60: 2007-2017. PMID: 10766192
4. Thévenod, F., et al. 2000. J. Biol. Chem. 275: 1887-1896. PMID: 10636889
5. Petegnief, V., et al. 2001. Neuroscience. 104: 223-234. PMID: 11311545
6. Kauppinen, T.M. and Swanson, R.A. 2005. J. Immunol. 174: 2288-2296. PMID: 15699164

Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (15 mg/ml), methanol, dichloromethane, DMF (~25 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Insoluble in water, and sparingly soluble in aqueous buffers.
Storage :
Store at -20° C
Melting Point :
128-130° C
Refractive Index :
n20D 1.56
IC50 :
ICAM-1: IC50 = 5-10 µM (human); VCAM-1: IC50 = 5-10 µM (human); E-selectin: IC50 = 5-10 µM (human); IL-6: IC50 = 5-10 µM (human); IL-8: IC50 = 5-10 µM (human); NFKBIA phosphorylation: IC50 = 10 µM; NF-kappa-B p65 subunit nuclear translocation: IC50 = 3 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UD1430000
PubChem CID :
5353431
MDL Number :
MFCD00712162
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N

Download SDS (MSDS)

Certificate of Analysis

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BAY 11-7082  Product Citations

See how others have used BAY 11-7082. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 94 total

PMID: # 30798416  Zhou, X. et al. 2019. Mol. Cell. Biochem.

PMID: # 30602116  Klug, YA. et al. 2019. Biochemistry. 58: 818-832.

PMID: # 31285364  Matilla, L. et al. 2019. Clin. Sci. 133: 1537-1548.

PMID: # 30659232  Salahuddin, S.|Fath, EK.|Biel, N.|Ray, A.|Moss, CR.|Patel, A.|Patel, S.|Hilding, L.|Varn, M.|Ross, T.|Cramblet, WT.|Lowrey, A.|Pagano, JS.|Shackelford, J.|Bentz, GL.| et al. 2019. Sci Rep. 9: 208.

PMID: # 31391172  Kunkemoeller, B. et al. 2019. Diabetes.

PMID: # 31019287  Li, S. et al. 2019. Lab. Invest.

PMID: # 30962542  Litke, JL.|Jaffrey, SR.| et al. 2019. Nat. Biotechnol.

PMID: # 30515817  Liao, W. et al. 2019. J. Cell. Physiol. 234: 12646-12662.

PMID: # 31361391  Laudisi, F. et al. 2019. Mol Oncol.

PMID: # 30756299  Ikram, M.|Muhammad, T.|Rehman, SU.|Khan, A.|Jo, MG.|Ali, T.|Kim, MO.| et al. 2019. Mol. Neurobiol.

Citations 1 to 10 of 94 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. BAY 11-7082, sc-200615, is in white powder or crystalline form.
Answered by: Chemical Support 4
Date published: 2017-05-02

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, BAY 11-7082 (CAS 19542-67-7), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-30
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Rated 5 out of 5 by from Working well Working well. Purity is good.
Date published: 2015-04-03
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