BAPTA, Tetrasodium SaltA high quality and sensitive compound for calcium signaling studies

BAPTA, Tetrasodium Salt (CAS 126824-24-6)

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Synonym: BAPTA-Na4; Tetrasodium 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetate
Application: A high quality and sensitive compound for calcium signaling studies
CAS Number: 126824-24-6
Molecular Weight: 564.36
Molecular Formula: C22H20N2O104Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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BAPTA, Tetrasodium Salt (1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salt) is a selective calcium chelator with 105-fold greater affinity for Ca2+ than for Mg2+. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. When BAPTA forms complexes with Ca2+, a UV spectrum shift from 254 to 279 nm occurs at pH >6.0. BAPTA, Tetrasodium Salt is useful for spectrophotometric monitoring of extracellular Ca2+ levels, with very little sensitivity to pH. Has also been used for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. Neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy have also been observed.
Additional BAPTA chelators available:
BAPTA, Free Acid (sc-201508)
BAPTA tetrapotassium salt (sc-202076)
BAPTA/AM (sc-202488)
BAPTA-APM (sc-206966)
BAPTA-TMFM (sc-212043)
5,5i difluoro Bapta(AM) (sc-217247)
5,5i difluoro Bapta(K+ Salt) (sc-217248)
Bapta-FF (AM) (sc-217696)


References

1. Tymianski, M., et al. 1994. J. Neurophysiol. 72: 1973-1992. PMID: 7823112
2. Li, L., et al. 1995. J. Cell. Physiol. 163: 105-114. PMID: 7896886
3. DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 14482-14487. PMID: 9826726

Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml).
Storage :
Store at -20° C
Boiling Point :
766.6° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.66 (Predicted)
Fluoresence :
λex 254 nm, λem 363 nm in water; λex 274 nm, λem 363 nm in with calcium
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16760309
MDL Number :
MFCD00067691
Beilstein Registry :
8818619
SMILES :
C1=CC=C(C(=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=CC=CC=C2N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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