BAPTA, Tetrasodium Salt (1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrasodium salt) is a selective calcium chelator with 105-fold greater affinity for Ca2+ than for Mg2+. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. When BAPTA forms complexes with Ca2+, a UV spectrum shift from 254 to 279 nm occurs at pH >6.0. BAPTA, Tetrasodium Salt is useful for spectrophotometric monitoring of extracellular Ca2+ levels, with very little sensitivity to pH. Has also been used for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. Neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy have also been observed.
Additional BAPTA chelators available:
BAPTA, Free Acid (sc-201508)
BAPTA tetrapotassium salt (sc-202076)
5,5i difluoro Bapta(AM) (sc-217247)
5,5i difluoro Bapta(K+ Salt) (sc-217248)
Bapta-FF (AM) (sc-217696)
1. Tymianski, M., et al. 1994. J. Neurophysiol. 72: 1973-1992. PMID: 7823112
2. Li, L., et al. 1995. J. Cell. Physiol. 163: 105-114. PMID: 7896886
3. DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 14482-14487. PMID: 9826726
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