BAPTA tetrapotassium saltA selective calcium chelator with greater affinity for Ca2+ than Mg2+

BAPTA tetrapotassium salt (CAS 73630-08-7)

BAPTA tetrapotassium salt | CAS 73630-08-7 is rated 5.0 out of 5 by 1.
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Synonym: 1,2-bis(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrapotassium salt; BAPTA⋅4K
Application: A selective calcium chelator with greater affinity for Ca2+ than Mg2+
CAS Number: 73630-08-7
Purity: ≥98%
Molecular Weight: 628.79
Molecular Formula: C22H20K4N2O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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BAPTA tetrapotassium salt (1,2-bis-(o-Aminophenoxy)-ethane-N,N,N′,N′-tetraacetic acid•4K) is a selective calcium chelator with 105-fold greater affinity for Ca2+ than for Mg2+. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction including apoptotic cascades, and neuroscience research. BAPTA and its derivatives are calcium chelators commonly used to form calcium buffers with well-defined calcium concentrations.
BAPTA free acid is not cell permeable and is useful for manipulating extracellular Ca2+ levels. BAPTA is closely related to the well-known chelator EGTA [ethylene glycol bis(beta-aminoethyl ether)-N,N,N′,N′-tetraacetic acid] (sc-3593), but is less effected by pH changes and are more efficient at taking up and releasing Ca2+.
Additional BAPTA chelators available:
BAPTA, Free Acid (sc-201508)
BAPTA/AM (sc-202488)
BAPTA-APM (sc-206966)
BAPTA-TMFM (sc-212043)
5,5i difluoro Bapta(AM) (sc-217247)
5,5i difluoro Bapta(K+ Salt) (sc-217248)
Bapta-FF (AM) (sc-217696)
BAPTA, Tetrasodium Salt (sc-278716)


References

1. Tsien, R.Y. 1980. Biochemistry. 19: 2396-2404. PMID: 6770893
2. Kijima, H. and Tanabe, N. 1988. J. Physiol. 403: 135-149. PMID: 3150982
3. Tanabe, N. and Kijima, H. 1988. Neurosci. Lett. 92: 52-57. PMID: 2847089
4. Tymianski, M., et al. 1994. J. Neurophysiol. 72: 1973-1992. PMID: 7823112
5. Li, L., et al. 1995. J. Cell. Physiol. 163: 105-114. PMID: 7896886
6. Jang, M.H., et al. 2004. Neurosci. Lett. 358: 189-192. PMID: 15039113
7. Hardie, R.C. 2005. Cell Calcium. 38: 547-556. PMID: 16140375

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at room temperature
Melting Point :
~250° C
Refractive Index :
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
126423
MDL Number :
MFCD00070080
SMILES :
C1=CC=C(C(=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=CC=CC=C2N(CC(=O)[O-])CC(=O)[O-].[K+].[K+].[K+].[K+]

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Certificate of Analysis

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BAPTA tetrapotassium salt  Product Citations

See how others have used BAPTA tetrapotassium salt. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 30733149  Abderemane-Ali, F.|Findeisen, F.|Rossen, ND.|Minor, DL.| et al. 2019. Neuron. 101: 1134-1149.e3.

PMID: # 27751234  Chen, N.|Sugihara, H.|Kim, J.|Fu, Z.|Barak, B.|Sur, M.|Feng, G.|Han, W.| et al. 2016. Elife. 5:

PMID: # 19254539  Lin, JY. et al. 2009. Biophys. J. 96: 1803-1814.

PMID: # 14742421  Heim, N. et al. 2004. J. Biol. Chem. 279: 14280-14286.

PMID: # 10669488  Ho, MW. et al. 2000. J. Neurophysiol. 83: 723-734.

PMID: # 9508829  Farkas, I. et al. 1998. J. Physiol. (Lond.). 507 ( Pt 3): 679-687.

PMID: # 9582224  Nishizaki, T. et al. 1998. J. Neurophysiol. 79: 2513-2521.

PMID: # 9369339  Arvanov, VL. et al. 1997. Brain Res. 768: 361-364.

PMID: # 1657308  Alreja, M. et al. 1991. Brain Res. 556: 339-343.

PMID: # 3150982  Kijima, H. et al. 1988. J. Physiol. (Lond.). 403: 135-149.

Citations 1 to 10 of 11 total
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Rated 5 out of 5 by from Heim et al Heim et al. (PubMed ID 14742421) used BAPTA tetrapotassium salt to obtain dissociation kinetics of E. coli via in vitro spectroscopy. -SCBT Publication Review
Date published: 2015-02-02
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