Bafilomycin C1An inhibitor of V-ATPase proteins

Bafilomycin C1 (CAS 88979-61-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 77ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: An inhibitor of V-ATPase proteins
CAS Number: 88979-61-7
Purity: >95%
Molecular Weight: 720.88
Molecular Formula: C39H60O12
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Bafilomycin C1 is a macrolide antibiotic inhibitor of membrane V-ATPase (vacuolar-type H+-ATPase) enzymes. The V-ATPase proteins are ATP-dependent proton pump structures which are highly conserved across many different types of organisms, including eukaryotes, bacteria, fungi, nemotodes, and plants. Bafilomycin C1, as well as Bafilomycin A (sc-201550) and the other compounds of the family, demonstrates antibacterial and antinematodal properties. V-ATPases on the osteoclast bone-apposed plasma membrane are crucial for the process of bone resorption, and excessive resorption is correlated to syndromes of deficient bone material such as osteoporosis; V-ATPase inhibitors such as Bafilomycin C1 represent potential interventional agents upon this bone resorption.


1. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 7972-7976. PMID: 2973058
2. Rautiala, T.J., et al. 1993. Biochem. Biophys. Res. Commun. 194: 50-56. PMID: 8333864
3. Lacey, E., et al. 1995. Int. J. Parasitol. 25: 349-357. PMID: 7601593
4. Xu, J., et al. 2007. Histol. Histopathol. 22: 443-454. PMID: 17290355

Physical State :
Derived From :
Streptomyces sp.
Solubility :
Soluble in 100% ethanol, methanol, DMF or DMSO. Note, forms methyl ketal on long term storage in methanol
Storage :
Store at -20° C
Boiling Point :
844.44° C at 760 mmHg (Predicted)
Density :
1.18 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 69ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 37ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.