Bafilomycin C1An inhibitor of V-ATPase proteins

Bafilomycin C1 (CAS 88979-61-7)

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Application: An inhibitor of V-ATPase proteins
CAS Number: 88979-61-7
Purity: >95%
Molecular Weight: 720.88
Molecular Formula: C39H60O12
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Bafilomycin C1 is a macrolide antibiotic inhibitor of membrane V-ATPase (vacuolar-type H+-ATPase) enzymes. The V-ATPase proteins are ATP-dependent proton pump structures which are highly conserved across many different types of organisms, including eukaryotes, bacteria, fungi, nemotodes, and plants. Bafilomycin C1, as well as Bafilomycin A (sc-201550) and the other compounds of the family, demonstrates antibacterial and antinematodal properties. V-ATPases on the osteoclast bone-apposed plasma membrane are crucial for the process of bone resorption, and excessive resorption is correlated to syndromes of deficient bone material such as osteoporosis; V-ATPase inhibitors such as Bafilomycin C1 represent potential interventional agents upon this bone resorption.


References

1. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 7972-7976. PMID: 2973058
2. Rautiala, T.J., et al. 1993. Biochem. Biophys. Res. Commun. 194: 50-56. PMID: 8333864
3. Lacey, E., et al. 1995. Int. J. Parasitol. 25: 349-357. PMID: 7601593
4. Xu, J., et al. 2007. Histol. Histopathol. 22: 443-454. PMID: 17290355

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in 100% ethanol, methanol, DMF or DMSO. Note, forms methyl ketal on long term storage in methanol
Storage :
Store at -20° C
Boiling Point :
844.44° C at 760 mmHg (Predicted)
Density :
1.18 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6441158
SMILES :
CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)O)O)O)OC)C

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Certificate of Analysis

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