Baccatin IIIAn apoptosis inducer and precursor to paclitaxel/taxol

Baccatin III (CAS 27548-93-2)

Baccatin III | CAS 27548-93-2 is rated 5.0 out of 5 by 1.
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Application: An apoptosis inducer and precursor to paclitaxel/taxol
CAS Number: 27548-93-2
Purity: ≥95%
Molecular Weight: 586.63
Molecular Formula: C31H38O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Baccatin III is the precursor to paclitaxel/ taxol. Antileukaemic and antitumor agent isolated from the bark of the Pacific yew tree (Taxus breviofolia). Baccatin III binds to tubules when they are assembled in the cell and stabilizes the polymerized form of tubules so that they remain assembled even under conditions in which microtubules dissociate into tubulin subunits. Baccatin III is also an inducer of apoptosis and shows antitumor properties in vitro


References

1. Miller, M.C. 3rd., Johnson, K.R., Willingham, M.C., Fan, W.Cancer Chemother. Pharmacol. 44:444-52 (1999). 2. Recent advances in the chemistry of taxol: D.G. Kingston; J. Nat. Prod. 63, 726 (2000) 3. Wheeler,N.C., J. Natl. Prod., 55, 432 (1992)

Physical State :
Solid
Solubility :
Soluble in DMSO, 100% ethanol, and methanol.
Storage :
Store at -20° C
Melting Point :
212-218° C
Boiling Point :
713.61° C at 760 mmHg (Predicted)
Density :
1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
65366
MDL Number :
MFCD00153921
SMILES :
CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Lee et al Lee et al. (PubMed ID 24957690) found that baccatin III decreased tumor progression by inhibiting the accumulation and suppressive function of myeloid-derived suppressor cells in mice. -SCBT Publication Review
Date published: 2015-01-07
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