AZD8055 is a selective ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. AZD8055 fully inhibits the rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1, resulting in significant inhibition of cap-dependent translation. AZD8055 inhibits proliferation and induces autophagy in H838 and A549 cells.
See how others have used AZD8055. Click on the entry to view the PubMed entry .
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