AzathioprineAn immunosuppressive antimetabolite that interferes with the synthesis of purines

Azathioprine (CAS 446-86-6)

Azathioprine | CAS 446-86-6 is rated 5.0 out of 5 by 1.
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Synonym: 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
Application: An immunosuppressive antimetabolite that interferes with the synthesis of purines
CAS Number: 446-86-6
Molecular Weight: 277.26
Molecular Formula: C9H7N7O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a Nucleic Acid Synthesis Inhibitor.


References

Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979), Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979), Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987), Sandborn, W.J., et al.: : Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998,)

Physical State :
Solid
Solubility :
Soluble in Dichloromethane and DMSO
Storage :
Store at -20° C
Melting Point :
251-253°C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UO8925000
PubChem CID :
2265
MDL Number :
MFCD00069203
EC Number :
207-175-4
SMILES :
CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]

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Azathioprine  Product Citations

See how others have used Azathioprine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28446589  Yamazaki, R. et al. 2017. FASEB J. 31: 3359-3371.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Wielenga Wielenga, MC. et al. (PubMed 25469037) reported that Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis. -SCBT Publication Review
Date published: 2015-04-26
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