AZ628A potent tyrosine protein inhibitor to wild-type Raf-1 and Raf-B V600E

AZ628 (CAS 878739-06-1)

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Synonym: 3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide
Application: A potent tyrosine protein inhibitor to wild-type Raf-1 and Raf-B V600E
CAS Number: 878739-06-1
Purity: ≥98%
Molecular Weight: 451.52
Molecular Formula: C27H25N5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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AZ628 is a potent tyrosine protein inhibitor to wild-type Raf-1 and Raf-B V600E with IC50 of 29 nM and 34 nM, respectively.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (90 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (< 1 mg/ml at 25 °C).
Storage :
Store at -20° C
Melting Point :
310.98° C (Predicted)
Boiling Point :
710.61° C (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
ACN: IC50 = 0.10 nM (human); SH-4: IC50 = 3.01 nM (human); wild-type CRAF: IC50 = 29 nM; BRAFV600E: IC50 = 34 nM; wild-type BRAF: IC50 = 100 nM
pK Values :
pKa: 12.92 (Predicted), pKb: 1.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11676786
MDL Number :
MFCD17392577
SMILES :
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C

Download SDS (MSDS)

Certificate of Analysis

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AZ628  Product Citations

See how others have used AZ628. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30763105  2019. Mol. Pharm. 16: 1423-1432.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. AZ628, sc-364418, is in off-white powder form.
Answered by: Chemical Support 4
Date published: 2017-05-16
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