AY 9944CAS: 366-93-8
MF: C22H28Cl2N2•2HCl
MW: 464.30
A hedgehog inhibitor and DHCR7 inhibitor.

AY 9944 (CAS 366-93-8)

AY 9944 | CAS 366-93-8 is rated 5.0 out of 5 by 1.
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Synonym: trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride
Application: A hedgehog inhibitor and DHCR7 inhibitor
CAS Number: 366-93-8
Purity: ≥99%
Molecular Weight: 464.30
Molecular Formula: C22H28Cl2N22HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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AY 9944 is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. AY 9944 inhibits DHCR7 (Δ7-dehydrocholesterol reductase) (IC50 = 13 nM), thus reducing cholesterol biosynthesis, and also inhibiting cholesterol esterification. AY 9944 may also directly block the cellular response to hedgehog proteins. AY 9944 is an inhibitor of EBP.


References

1. Yoshida, Y., et al., 1985. Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs. Journal of biochemistry. 98(6): 1669-79. PMID: 2419314
2. Kraml, M., et al., 1964. Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochemical and biophysical research communications. 15(5): 455-7. PMID: 4283982
3. Moebius, F F., et al., 1998. Molecular cloning and expression of the human delta7-sterol reductase. Proceedings of the National Academy of Sciences of the United States of America. 95(4): 1899-902. PMID: 9465114
4. Cooper, M K., et al., 1998. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science (New York, N.Y.). 280(5369): 1603-7. PMID: 9616123
5. Incardona, J P., et al., 1998. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development (Cambridge, England). 125(18): 3553-62. PMID: 9716521
6. Gofflot, F., et al., 2001. Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis. Developmental dynamics : an official publication of the American Association of Anatomists. 220(2): 99-111. PMID: 11169843

Physical State :
Solid
Solubility :
Soluble in water (50 mM), and DMSO (14 mg/ml).
Storage :
Desiccate at 4° C
Melting Point :
288-293.5° C (lit.)
Refractive Index :
n20D ~1.57 (Predicted)
IC50 :
DHCR7: IC50 = 13 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GU7025000
PubChem CID :
9704
MDL Number :
MFCD01734586
SMILES :
C1CC(CCC1CNCC2=CC=CC=C2Cl)CNCC3=CC=CC=C3Cl.Cl.Cl

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AY 9944  Product Citations

See how others have used AY 9944. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30212566  Zhou, W.|Debnath, A.|Jennings, G.|Hahn, HJ.|Vanderloop, BH.|Chaudhuri, M.|Nes, WD.|Podust, LM.| et al. 2018. PLoS Pathog. 14: e1007245.

PMID: # 26923021  Kim, Y. et al. 2016. J. Alzheimers Dis. 51: 1057-68.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Jung Jung, S. et al. (PubMed 25890840) administered AY 9944, a hedgehog and DHCR7 inhibitor, during the postnatal developmental period of mice to induce atypical absence epilepsy. -SCBT Publication Review
Date published: 2015-06-23
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