AureothricinAn antibiotic and analog of thiolutin

Aureothricin (CAS 574-95-8)

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Application: An antibiotic and analog of thiolutin
CAS Number: 574-95-8
Purity: >98%
Molecular Weight: 242.3
Molecular Formula: C9H10N2O2S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interestin this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Aureothricin is an inhibitor of RNA Polymerase.


References

1. Tipper, DJ. 1973. J. Bacteriol. 116: 245-256. PMID: 4583213
2. Minamiguchi, K., et al. 2001. Int. J. Cancer. 93: 307-316. PMID: 11433393
3. Jimenez,A., et al. 1973. Antimicrob Agents Chemother. 3: 729-738. PMID: 4597739

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO, DMF, methanol (partialy), 100% ethanol (partially), and water (poorly).
Storage :
Store at -20° C
Melting Point :
281-282° C
Boiling Point :
479.15° C at 760 mmHg (Predicted)
Density :
1.49 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
pK Values :
pKb: 10.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
68460
MDL Number :
MFCD07370147
SMILES :
CCC(=O)NC1=C2C(=CSS2)N(C1=O)C

Download SDS (MSDS)

Certificate of Analysis

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