Atovaquone CAS: 95233-18-4
MF: C22H19ClO3
MW: 366.84
An inhibitor of mitochondrial electron transport.

Atovaquone (CAS 95233-18-4)

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Application: An inhibitor of mitochondrial electron transport
CAS Number: 95233-18-4
Molecular Weight: 366.84
Molecular Formula: C22H19ClO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Atovaquone is antipneumocystic hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport.


Hudson, A.T., et al.: Drugs Exp. Clin. Res., 17, 427 (1991) Fry, M., et al.: Biochem. Pharmacol., 43, 1545 (1992) El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998)

Appearance :
Physical State :
Solubility :
Soluble in water (<1 mg/ml at 25° C), DMSO (>10 mg/ml), chloroform, methanol, and ethanol (<1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
216-219° C
Boiling Point :
~535° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 0.3 nM; Plasmodium yoelii: IC50 = 1 nM; Babesia divergens: IC50 = 2.37 nM; Toxoplasma gondii: IC50 = 8.18 nM; Toxoplasma gondii RH: IC50 = 136.3 nM
Ki Data :
Plasmodium falciparum DHODH : Ki= 27 µM
pK Values :
pKa: 5.01 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 866
Beilstein Registry :
OC1=C(C2CC[[email protected]@H](CC2)C2=CC=C(Cl)C=C2)C(=O)C2=C(C=CC=C2)C1=O

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Certificate of Analysis

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Atovaquone  Product Citations

See how others have used Atovaquone. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30700707  LaMonte, GM.|Orjuela-Sanchez, P.|Calla, J.|Wang, LT.|Li, S.|Swann, J.|Cowell, AN.|Zou, BY.|Abdel-Haleem Mohamed, AM.|Villa Galarce, ZH.|Moreno, M.|Tong Rios, C.|Vinetz, JM.|Lewis, N.|Winzeler, EA.| et al. 2019. Nat Commun. 10: 488.

PMID: # 29542317  Orjuela-Sanchez, P. et al. 2018. ACS Infect Dis. 4: 531-540.

Citations 1 to 2 of 2 total
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