ATM/ATR Kinase InhibitorCAS: 905973-89-9
MF: C23H18Cl3FN4O3S
MW: 555.84
A cell-permeable compound that inhibits kinase activity of ATM / ATR.

ATM/ATR Kinase Inhibitor (CAS 905973-89-9)

ATM/ATR Kinase Inhibitor | CAS 905973-89-9 is rated 5.0 out of 5 by 1.
  • y_2020, m_1, d_19, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202964, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 140ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: CGK733
Application: A cell-permeable compound that inhibits kinase activity of ATM / ATR
CAS Number: 905973-89-9
Purity: ≥95%
Molecular Weight: 555.84
Molecular Formula: C23H18Cl3FN4O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

ATM/ATR Kinase Inhibitor (CGK733) was originially published as a cell permeable compound that selectively inhibits the kinase activity of ATM and ATR at an IC50 ~ 200 nM without significant effect against other PIKK family members DNA-PK, mTOR and PI 3-kinase (PI3K) or kinases that are known to phosphorylate p53 (ERK, Cytokeratin 1(CAK), Cdk2, JNK, PKC, cyclin H(CAK), Chk1, PKR, and p38). The claims of this product we retracted and the effect of the ATM/ATR Kinase Inhibitor (CGK733) have not been fully investigated.


References

1. Won, J., et al. 2006. Nat. Chem. Biol. 2: 369-374. RETRACTED PMID: 16767085
2. Crescenzi, E., et al. 2008. Clin. Cancer Res. 14: 1877-1887. PMID: 18347191
3. Cruet-Hennequart, S., et al. 2008. DNA Repair. 7: 582-596. PMID: 18289945
4. Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. 229: 20-32. PMID: 18289623

Physical State :
Solid
Solubility :
Soluble in DMSO (>5 mg/ml).
Storage :
Store at 4° C
Density :
1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
Serine-protein kinase ATM: IC50 = 200 nM (human); Serine-protein kinase ATR: IC50 = 200 nM (human)
pK Values :
pKa: 10.15 (Predicted), pKb: 0.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6605258
MDL Number :
MFCD09038682
SMILES :
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

ATM/ATR Kinase Inhibitor  Product Citations

See how others have used ATM/ATR Kinase Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 26259235  Wang, Y. et al. 2015. Oncotarget. 6: 25252-65.

PMID: # 26486079  2015. Oncotarget. 6: 39692-701.

PMID: # 24375454  2014. Eur. J. Immunol. 44: 1108-18.

PMID: # 23787466  2013. Biol. Chem. 394: 1325-31.

PMID: # 19656853  Lim, CH. et al. 2009. Mol. Biol. Cell. 20: 4183-4193.

Citations 1 to 5 of 5 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 128ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Alao Alao, JP. et al. (PubMed 19903334) used ATM/ATR Kinase Inhibitor in conjunction with Caffeine (sc-202514), to study their effects on human cancer cell lines. They found that exposure to caffeine and CGK773 was associated with rapid decline in cyclin D1 and inhibition of cell proliferation. -SCBT Publication Review
Date published: 2015-05-28
  • y_2020, m_1, d_19, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.4
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202964, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.