ATB-343A hybrid molecule of the NSAID indomethacinan and an H2S donor

ATB-343 (CAS 1000700-26-4)

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Application: A hybrid molecule of the NSAID indomethacinan and an H2S donor
CAS Number: 1000700-26-4
Molecular Weight: 566.1
Molecular Formula: C28H20ClNO4S3
* Refer to Certificate of Analysis for lot specific data (including water content).
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ATB-343 is a hybrid molecule of the NSAID indomethacinan and a hydrogen sulfide (H2S) donor. In rats, ATB-343 does not cause gastric damage or promote leukocyte adherence to vascular endothelium, unlike indomethacin alone. These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective antiinflammatory agents than traditional NSAIDs on their own.


References

1. Kiriyama, M., et al., 1997. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British journal of pharmacology. 122(2): 217-24. PMID: 9313928
2. Wallace, John L., et al., 2007. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends in pharmacological sciences. 28(10): 501-5. PMID: 17884186

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25066195
SMILES :
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)OC4=CC=C(C=C4)C5=CC(=S)SS5

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Certificate of Analysis

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