AT7519 CAS: 844442-38-2
MF: C16H17Cl2N5O2
MW: 382.24
A novel small molecule effective as a pan-Cdk inhibitor for Cdk1, Cdk2, Cdk3, Cdk4, Cdk5 and Cdk6.

AT7519 (CAS 844442-38-2)

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Alternate Names: 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide
Application: AT7519 is a novel small molecule effective as a pan-Cdk inhibitor for Cdk1, Cdk2, Cdk3, Cdk4, Cdk5 and Cdk6
CAS Number: 844442-38-2
Molecular Weight: 382.24
Molecular Formula: C16H17Cl2N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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AT7519 is a novel small molecule effective as a multi-cyclin-dependent kinase inhibitor for Cdk1/cyclin B (IC50 = 210 nM), Cdk2/Cyclin A (IC50 = 47 nM), Cdk3/Cyclin E (IC50 = 360 nM), Cdk4/Cyclin D1 (IC50 = 100 nM), Cdk5/p35 (IC50 = 13 nM) and Cdk6/Cyclin D3 (IC50 = 170 nM). AT7519 is an ATP competitive Cdk inhibitor with a Ki value of 38 nM for Cdk1. AT7519 is inactive against all non-Cdk kinases with the exception of GSK3β (IC50 = 89 nM). AT7519 shows potent antiproliferative activity in a variety of human tumor cell lines with IC50 values ranging from 40 nM for MCF-7 to 940 nM for SW620. AT7519 induces activation of GSK-3β by down-regulating GSK-3β phosphorylation, which also contributes to AT7519 induced apoptosis independent of the inhibition of transcription.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml) at 25°C, water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25°C.
Storage :
Store at -20° C
Melting Point :
285.07° C (Predicted)
Boiling Point :
~586.0° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
CDK5/p35: IC50 = 13 nM; CDK2/Cyclin A: IC50 = 47 nM; CDK4/Cyclin D1: IC50 = 100 nM; CDK6/Cyclin D3: IC50 = 170 nM; CDK1/cyclin B: IC50 = 210 nM
Ki Data :
CDK1: Ki= 38 nM
pK Values :
pKa: 11.1 (Predicted), pKb: 9.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD13184820
SMILES :
C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl

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Certificate of Analysis

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AT7519 (CAS 844442-38-2)  Product Citations

See how others have used AT7519 (CAS 844442-38-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25846820  Mol. Neurobiol. 1959-1976.

Citations 1 to 1 of 1 total
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