AST 1306A potent and selective inhibitor of EGFR phosphorylation

AST 1306 (CAS 1050500-29-2)

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Synonym: AST-6; AST1306 (p-Toluenesulfonic acid); AST 1306 (p-Toluenesulfonic acid)
Application: A potent and selective inhibitor of EGFR phosphorylation
CAS Number: 1050500-29-2
Molecular Weight: 621.08
Molecular Formula: C24H18ClFN4O2•C7H8O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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AST 1306 is a potent(pM) and selective inhibitor of EGFR and ErbB4 (IC50 = 500pM and 800 pM, respectively). AST 1306 blocks phosphorylation of EGFR and also prevents downstream pathways. AST 1306 also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line.


References

1. Xie H, et al. PLoS One. 2011, 6(7), e21487.

Physical State :
Solid
Solubility :
Soluble in DMSO (124 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (<1 mg/mL at 25 °C). Insoluble in 0.5% hydroxyethyl cellulose.
Storage :
Store at 4° C
IC50 :
EGFR: IC50 = 0.5 nM; ErbB4: IC50 = 0.8 nM; ErbB2: IC50 = 3.0 nM; T790M/L858R: IC50 = 12 nM; FLT1: IC50 = >10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25027665
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

Download SDS (MSDS)

Certificate of Analysis

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