Asenapine (CAS 65576-45-6)

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Application: Asenapine is a combined 5HT2, adrenergic, and D2 receptor antagonist

CAS Number: 65576-45-6

Molecular Weight: 285.77

Molecular Formula: C₁₇H₁₆ClNO

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors.

References

Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989), Schotte, A., et al.: Brain Res., 631, 191 (1993), Andree, B., et al.: Psychopharmacology, 131, 339 (1997), Richelson, E., et al.: Life Sci., 68, 29 (2000),

Appearance :

Oil

Physical State :

Liquid

Solubility :

Soluble in Chloroform

Storage :

Store at -20° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

163091

SMILES :

CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24

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Asenapine (CAS 65576-45-6)

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References

Download SDS (MSDS)

Certificate of Analysis