AsenapineCAS: 65576-45-6
MF: C17H16ClNO
MW: 285.77
A combined 5HT2, adrenergic, and D2 receptor antagonist.

Asenapine (CAS 65576-45-6)

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Application: A combined 5HT2, adrenergic, and D2 receptor antagonist
CAS Number: 65576-45-6
Molecular Weight: 285.77
Molecular Formula: C17H16ClNO
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Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors.


References

Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989), Schotte, A., et al.: Brain Res., 631, 191 (1993), Andree, B., et al.: Psychopharmacology, 131, 339 (1997), Richelson, E., et al.: Life Sci., 68, 29 (2000),

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in Chloroform
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
163091
SMILES :
CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24

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